Clinical study on HDACIs… (2009)

By Guy D’Anjou, M.D. FRCPC Neurologist, Sainte-Justine Hospital Friedreich’s ataxia (FA) is one of the most frequent neurodegenerative diseases. Its clinical manifestations appear at a critical stage in the development of an individual and affect his autonomy and quality of life. A number of years ago it was discovered that...

Continue reading

Effects of buspirone on brain indoleamines and catecholamines in wild-type mice and Lurcher mutants (2000) [Funded by CAFA]

Reader, Tomas, A.; Ase, Ariel, R.; Le-Marec, Nathalie; Lalonde, Robert, 2000: Effects of buspirone on brain indoleamines and catecholamines in wild-type mice and Lurcher mutants. European Journal of Pharmacology 398(1): 41-51 [Funded by CAFA] Abstract The effects of a chronic serotoninergic stimulation on brain monoamine levels and metabolism were studied...

Continue reading

Les caractéristiques neuropsychologiques de l’ataxie de Friedreich (2002) [Funded by CAFA]

Les caractéristiques neuropsychologiques de l’ataxie de Friedreich (2002), Robert Lalonde, Catherine Strazielle Résumé L’ataxie de Friedreich provient de l’expansion du triplet guanine-adénine-adénine du gène FRDA. Les patients se caractérisent par d’importants troubles sensorimoteurs causés par une dégénérescence cérébelleuse associée à des lésions majeures des voies spino-cérébelleuses, corticos pinales et lemniscates....

Continue reading